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The modern management of red cell alloimmunisation

Department of Obstetrics, Leiden University Medical Centre, Netherlands. email: D.Oepkes{at}lumc.nl

Fetal and neonatal haemolytic disease, caused by red cell alloimmunisation, continues to occur despite well-organised prophylaxis programmes. In the average obstetric practice pregnancies complicated by the presence of red cell alloantibodies are now a rarity. Increasingly, these patients are referred to the few specialised fetal medicine units where a team of obstetricians, neonatologists, haematologists, laboratory technicians and transfusion specialists take care of the management in close collaboration. In all these fields advances were made in the last decade, further improving the care of women with this potentially serious condition. In this review current insights and new developments are summarised.

Keywords Keywords / rhesus / alloimmunisation / fetal anaemia / haemolytic disease / pregnancy