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Management of endometrial cancer

King's College Hospital, Denmark Hill, London SES 9RS. UK. email: fglawton{at}doctonorg.uk

Traditionally endometrial cancer has been considered a relatively benign disease with an overall five-year survival rate of around 75%. However, one-quarter of patients with this disease are dead within five years of diagnosis. Randomised controlled trials of radiotherapy in this disease are rare and many patients at little risk of recurrent disease, cured by surgery alone, are still referred for adjuvant radiotherapy. Lymph node status is a known prognostic factor but it is not yet known whether lymphadenectomy is of therapeutic significance. The roles of chemotherapy and hormonal therapy remain to be defined. Most patients are treated outside of trials and this situation must be addressed if improvements in treatment are to be seen.

Keywords Keywords / endometrial cancer / lymphadenectomy / prognostic factors / radiotherapy / surgery