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Familial screening for gynaecological and breast cancer

Wessex Clinical Genetics Service, The Princess Anne Hospital, Coxford Road, Southampton SO16 5YA UK. email: del{at}soton.ac.uk

This article covers basic principles of cancer genetics including carcinogenesis and genetic susceptibility and taking and interpreting a family history of cancer. The main emphasis is on common situations where a family history of ovarian, breast or endometrial cancer has practical implications for patients and several illustrative examples of family pedigrees are used to help clarify key points. Genes that are known to confer a high risk of certain types of cancer are discussed.

Keywords Keywords / cancer / genetic testing / heredity / risk / treatment