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Trophoblastic diseases and pregnancy

Academic and Departments of Obstetrics and Gynaecology, Royal Free and University College London Medical School, University College London, 86-96 Chenies Mews, London WC1E 6HX UK. email: e.jauniaux{at}ucl.ac.uk

Gestational trophoblastic disease (GTD) is a term commonly applied to a spectrum of interrelated disorders originating from the placental trophoblast. These include complete, partial and invasive moles, placental site trophoblastic tumours and choriocarcinomas. Modern genetic and molecular biology techniques enable rapid and accurate diagnosis and have contributed to a better understanding of the pathophysiology of GTD. As a result most women can be treated before they develop severe complications. This review addresses the perinatal diagnosis of GTD and focuses on the roles of ultrasound and Doppler examination in prenatal diagnosis and the importance of histopathology in the postnatal diagnosis of GTD.

Keywords Keywords / gestational trophoblastic disease (GTD) / human chorionic gonadotropin (hCG) / hydatidiform mole / trophoblastic tumour