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HELLP syndrome

Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LS2 9NS. email: drtraceyglanville{at}hotmail.com (corresponding author)

James Walker, FRCOG, Professor of Obstetrics and Gynaecology

St James' Hospital, Beckett Street, Leeds LS9 7TS, UK.

Hypertensive disease including the multisystem form of HELLP syndrome remains an important cause of maternal mortality. HELLP syndrome is characterised by haemolysis, elevated liver enzymes and low platelets. The origins of the disease are in the placenta although the pathogenesis is not clearly understood. In this review the clinical features and demographics are examined together with the diagnostic criteria. Advances have been made in the management of HELLP syndrome, although larger studies are needed before the introduction of these new methods into routine practice. Delivery, fetal and maternal outcomes and management in a subsequent pregnancy are also discussed.

Keywords Keywords / HELLP / pre-eclampsia / haemolysis / liver enzymes / platelets