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Haemoglobinopathies in pregnancy

Consultant in Fetal Maternal Medicine, Department of Obstetrics, St Mary's Hospital for Women and Children, Oxford Road, Manchester, M13 9WL, UK. email: tracey.johnston{at}cmmc.nhs.uk

The haemoglobinopathies are a complex group of red blood cell disorders. The ethnic diversity of the population in many parts of the UK means that these disorders are increasingly being seen in the antenatal setting. With the planned introduction of both antenatal and newborn screening programmes for haemoglobinopathies in England and Wales, a review of the subject is timely. This article explains the genetic background and clinical features of the major haemoglobinopathies, discusses antenatal screening and prenatal diagnosis, and highlights the implications of pregnancy for women with these disorders.

Keywords Keywords / haemoglobinopathy / prenatal diagnosis / screening / sickle cell disease / thalassaemia

This article has been cited by other articles:

				C. F. Wright and H. Burton The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis Hum. Reprod. Update, October 22, 2008; (2008) dmn047v1. [Abstract] [Full Text] [PDF]