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Current thoughts on the pathogenesis of pre-eclampsia

Maternal and Fetal Health Research Centre, St Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK E-mail: rasmith{at}doctors.org.uk (corresponding author)

Louise C Kenny, PhD MRCOG, Senior Lecturer and Consultant Obstetrician

St Mary's Hospital, Manchester, UK

Pre-eclampsia remains a leading cause of maternal and perinatal morbidity and mortality. In this review we examine the leading hypotheses of the pathogenesis of this disorder and discuss recent research in this area that has led to the exciting prospect of new treatments for this devastating condition.

Keywords maternal mortality / pathogenesis / pre-eclampsia