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Update on human papillomavirus vaccines

Department of Obstetrics and Gynaecology, Wales College of Medicine Cardiff University, Heath Park, Cardiff, CF14 4XN, UK E-mail: fianderan{at}cf.ac.uk

While progress has been slow in the field of therapeutic vaccination, the subject of prophylactic vaccination has hit the headlines and generated much interest. Results from trials of prophylactic vaccination are exciting and demonstrate that virus-like particle vaccines are safe, immunogenic and effective at protecting against persistent human papilloma virus infection and intraepithelial neoplasia. However, a number of important and complex issues need to be addressed for successful implementation, including scientific, economic, epidemiological and psychosocial considerations.

Keywords cervical neoplasia / human papillomavirus / lower genital tract neoplasia / prophylactic vaccination / therapeutic vaccination